New Brunswick, New Jersey 08903

  • Prostate Cancer


RATIONALE: Measuring bone mineral density may help doctors predict whether prostate cancer will come back. It may also help the study of prostate cancer in the future. PURPOSE: This clinical trial is studying whether bone mineral density affects cancer recurrence in patients with early stage prostate cancer.

Study summary:

OBJECTIVES: - Determine bone mineral density (BMD) in patients with clinically significant early stage prostate cancer. - Determine whether patients who have a higher level of BMD and have had a radical prostatectomy for cure are less likely to have an early relapse (i.e., less than 3 years) than those patients with a low level of BMD. OUTLINE: This is a case-controlled study followed by a prospective, longitudinal, cohort study. Patients undergo bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry with a densitometer. Posteroanterior measurements of the total hip are also recorded. Patients also undergo blood collection to examine markers that provide evidence of systemic disease. Patients are followed every 6 months for 3 years. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.


DISEASE CHARACTERISTICS: - Biopsy-confirmed early stage prostate cancer - Disease localized within the capsule - No evidence of regional or distant spread (i.e., T1-2, N0, M0 disease) - A cohort of patients must have undergone a prior radical prostatectomy - Prostate specific antigen < 12 ng/mL - Gleason score ≥ 6 PATIENT CHARACTERISTICS: - Creatinine clearance ≤ 2.0 mg/dL - No Paget's disease - No hyperthyroidism or hypothyroidism - No Cushing's disease - No chronic liver disease - No major health problems that would cause a significant reduction in mobility or activities of daily living PRIOR CONCURRENT THERAPY: - See Disease Characteristics - No prior bisphosphonates, thyroxin, or calcitonin - No prior agents that suppress PSA levels (e.g., finasteride) - No prior androgen or estrogen therapy - More than 12 months since prior glucocorticoids - More than 12 months since prior herbal supplements that are known to lower PSA levels



Primary Contact:

Principal Investigator
Stephen W. Marcella, MD, MPH
Cancer Institute of New Jersey

Backup Contact:


Location Contact:

New Brunswick, New Jersey 08903
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: April 03, 2020

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