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Piscataway, New Jersey 08854


Purpose:

This study will determine the efficacy of a medication switch to Aripiprazole for the treatment of schizophrenia or schizoaffective disorder in patients with moderate to high symptoms of social anxiety. Specifically the study will test the possibility that a medication switch to Aripiprazole reduces symptoms of social anxiety in this patient population.


Study summary:

Although research has shown that social anxiety is very common among patients suffering from schizophrenia or schizoaffective disorder, it is rarely diagnosed and treated in this patient population. This study will determine the efficacy of a medication switch to Aripiprazole for the treatment of schizophrenia in patients with moderate to high symptoms of social anxiety. Specifically the study will test the possibility that a medication switch to Aripiprazole reduces symptoms of social anxiety in this patient population. In addition, the study will test the possibility that Aripiprazole significantly improves social adjustment, quality of life and level of functioning in these patients. The study may also assess the ability of Aripiprazole to reduce sexual dysfunction.


Criteria:

Inclusion Criteria 1. Patients meeting DSM IV diagnostic criteria for schizophrenia or schizoaffective disorder. 2. Patients presenting with comorbid social anxiety symptoms of moderate to high severity are eligible for participation in the study. Only patients with LSAS scores above 30* qualify for the study. 3. Age 18-65 4. Gender: males or females 5. Females: non-pregnant, not of child-bearing potential; if of child-bearing age must be on contraceptive such as pill or shot (condom alone not sufficient) 6. Good general health Exclusion Criteria: 1. Patient does not meet DSM IV diagnostic criteria for schizophrenia or schizoaffective disorder 2. Patient carries a diagnosis of dementia, degenerative CNS disorders, mental retardation, substance abuse or dependence other than nicotine dependence or alcohol abuse will be excluded from the study. 3. Patients with acute medical conditions are not eligible. 4. Patients allergic or otherwise intolerant or non-responsive to Aripiprazole 5. Patient with history of suicidal, homicidal or assaultive plans or attempts in the past 6 months. 6. Clinically significant EKG or lab abnormalities


NCT ID:

NCT00177008


Primary Contact:

Principal Investigator
Theodore Petti, MD, MPH
University of Medicine and Dentistry New Jersey


Backup Contact:

N/A


Location Contact:

Piscataway, New Jersey 08854
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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