Expired Study
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Nashville, Tennessee 37232


We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to critically ill patients with acute renal failure (ARF).


Inclusion Criteria: - Adults ≥ 18 years of age admitted to the intensive care unit - New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease - ARF will be defined by a sustained (over 24 hours) increase in serum creatinine > 0.5 mg/dl from baseline - Patients will be recruited for the study within 3-5 days following establishment of ARF Exclusion Criteria: - Institutionalized patient - Previous kidney transplant - Pregnancy - Unable to obtain consent from subject or legally recognized representative - ARF from urinary tract obstruction or a volume responsive pre-renal state. - Liver Failure - Recent cerebrovascular accident (CVA) - Coagulopathy defined as: Platelets < 50, PT > 20, INR > 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion. - Life expectancy < 48 hours



Primary Contact:

Principal Investigator
Alp Ikizler, MD
Vanderbilt University

Backup Contact:


Location Contact:

Nashville, Tennessee 37232
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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