Expired Study
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Baltimore, Maryland 21287


This study tests the hypothesis that allopurinol, a xanthine oxidase inhibitor, improves heart metabolism in patients with heart failure.

Study summary:

Xanthine oxidase have been reported to improve mechano-energetic coupling in failing hearts. The investigators developed a means to directly measure creatine kinase flux, the major energy reserve of the heart, in the human heart exploiting new magnetic resonance technologies. The investigators propose to study 10 healthy subjects and up to 25 with heart failure (dilated cardiomyopathy) before and after a single 300mg IV infusion of allopurinol.


Inclusion Criteria: 1. Age > 18 years 2. The patient is willing and able to provide informed consent 3. Clinical diagnosis of chronic heart failure 4. EF < 40% by echocardiography, nuclear MUGA or cath ventriculography 5. No significant coronary disease at cardiac catheterization 6. NYHA Class I-IV symptoms 7. Clinical stabilization for two weeks if following recent CHF decompensation. Exclusion Criteria: 1. Metallic implant prohibiting MR evaluation 2. Inability to lie flat for MR study 3. Administration of additional investigational drugs 4. Calculated creatinine clearance < 50 mL/min 5. Allergy to allopurinol 6. Current gout flare 7. Currently taking oral allopurinol



Primary Contact:

Principal Investigator
Robert G Weiss, MD
Johns Hopkins University

Robert G Weiss, MD
Phone: 410-955-1703
Email: rweiss@jhmi.edu

Backup Contact:


Location Contact:

Baltimore, Maryland 21287
United States

Tricia Steinberg, RN
Phone: 443-287-3469
Email: asteinb3@jhmi.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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