Baltimore, Maryland 21205

  • Heart Failure, Congestive


The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Study summary:

This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.


Inclusion Criteria: - age > 18 years - Healthy subjects: no history of heart disease - Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40% - Left ventricular hypertrophy: wall thickness >1.2cm - Coronary artery disease: >50% coronary lesion or positive stress test Exclusion Criteria: - contraindication to MRI



Primary Contact:

Principal Investigator
Robert G. Weiss, MD
Johns Hopkins University

Robert G. Weiss, MD
Phone: 410-955-1703

Backup Contact:


Location Contact:

Baltimore, Maryland 21205
United States

Tricia Steinberg, RN, MSN
Phone: 443-287-3469

Site Status: Recruiting

Data Source:

Date Processed: April 07, 2020

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