Expired Study
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San Francisco, California 94143


Purpose:

Collect DNA from well-characterized healthy volunteers.


Study summary:

DNA and plasma will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations. Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.


Criteria:

Inclusion Criteria: - Healthy adult subjects of both genders and specified ethnic groups - Subjects must be between 18-40 years of age Exclusion Criteria: - Smokers - Drink > 2 alcoholic beverages/day - Take any chronic medication


NCT ID:

NCT00187668


Primary Contact:

Principal Investigator
Kathleen M Giacomini, PhD
University of California, San Francisco


Backup Contact:

N/A


Location Contact:

San Francisco, California 94143
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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