Expired Study
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Ann Arbor, Michigan 48109


Purpose:

The purpose of this study is to explore how a sarcoma is affected by and the side effects of a newer combination of chemotherapy drugs(gemcitabine and docetaxel)as compared to a standard combination of chemotherapy drugs, ifosfamide and doxorubicin.


Study summary:

The purpose of this study is to explore the relative activity and toxicity of a newer combination of chemotherapy drugs, gemcitabine and docetaxel, as compared to a standard combination of chemotherapy drugs, ifosfamide and doxorubicin. Ifosfamide and Doxorubicin, given in combination, are recognized as a standard of care for some types of sarcoma. Both gemcitabine and docetaxel are approved by the US Food and Drug Administration (FDA) for the treatment of some cancers (cancers of the pancreas, lung) because patients with those cancers treated with either gemcitabine or docetaxel experienced shrinkage of their tumor or improvement in their symptoms. However, neither gemcitabine or docetaxel is approved for sarcoma, but the combination of gemcitabine and docetaxel is a standard treatment for advanced sarcoma.


Criteria:

Inclusion Criteria: - no evidence of metastasis - soft tissue sarcoma - intermediate or high histologic grade - greater than 5 cm - Zubrod performance status 1 or better - age 10 or older Exclusion Criteria: - clear cell, alveolar soft part, Ewing's rhabdosarcoma, undifferentiated small cell or Kaposi's - prior chemotherapy - nephrectomy - active unstable angina pectoris - concurrent therapy


NCT ID:

NCT00189137


Primary Contact:

Principal Investigator
Scott Schuetze, MD, PhD
University of Michigan Cancer Center


Backup Contact:

N/A


Location Contact:

Ann Arbor, Michigan 48109
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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