Expired Study
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Cleveland, Ohio 44106


Purpose:

The purpose of this research study is to analyze the effectiveness and tolerability of a medication, valproate ( Depakote and Depakote ER), in individuals age 50 years and older who have schizophrenia.


Study summary:

It is known that up to 30% of individuals with schizophrenia continue to have symptoms even when treated with current FDA-approved medications intended to treat their schizophrenia. Anticonvulsant medications such as valproate (Depakote and Depakote ER) are known to be effective for related conditions such as bipolar disorder (manic depressive illness), and are also used by some physicians in clinical settings in combination with antipsychotic medications to treat symptoms of schizophrenia. Currently Depakote and Depakote ER are approved by the FDA to treat bipolar disorder and to treat seizure disorder. This study will test to see if Depakote and Depakote ER may improve symptoms of schizophrenia as well when added to antipsychotic medications.


Criteria:

Inclusion Criteria: - Must have a diagnosis of schizophrenia as confirmed by the MINI - Must be on antipsychotic medication - Must be age 50 year or older - Must be capable of providing written informed consent for study participation. In situations where individuals have guardians of person, guardian and subject must both provide written consent; and - Must live in the Northeast Ohio area. Exclusion Criteria: - A primary psychiatric DSM Axis I diagnosis other than schizophrenia - Actively abusing substances; or - Medically unstable.


NCT ID:

NCT00194025


Primary Contact:

Principal Investigator
Martha Sajatovic, MD
Case Western Reserve University School of Medicine


Backup Contact:

N/A


Location Contact:

Cleveland, Ohio 44106
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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