Indianapolis, Indiana 46202

  • Thymic Carcinoma

Purpose:

To study the efficacy of Alimta as a single agent in thymic cancers


Study summary:

The broad range of clinical activity of thymic carcinomas makes the likelihood of detecting efficacy of a single agent such as premetrexed a reasonable objective since these malignancies are relatively slow growing and exhibit a broad range of chemosensitivity to antineoplastic agents.


Criteria:

Inclusion Criteria: - Histologically confirmed invasive, recurrent or metastatic thymoma or thymic carcinoma not amenable to potentially curative therapy by surgery. Original biopsy of tumor is sufficient for diagnoses unless otherwise clinically indicated. - Patients must have measurable disease with at least one bidimensional measurable lesion. Any scans or x-rays used to document measurable disease must be obtained with 6 weeks prior to registration. - Patients may have had prior chemotherapy for metastatic disease - Adequate organ function as defined by: bili </=1.5; calc. crt clr of >/=45; hematologic-granulocytes >/=1500 & plt >/=100K. - Patients who are receiving a stable dose of corticosteroids for myasthenia gravis are eligible. - ECOG performance status of 0 or 1 Exclusion Criteria: - Acute intercurrent infection or complications - pregnancy or lactating patients - Inability to interrupt aspirin or other nonsteroidal anti-inflammatory agents for a 5-day period (8-day period for long-acting agents. - Presence of clinically relevant third-space fluid collections that cannot be controlled by a procedure


NCT ID:

NCT00198133


Primary Contact:

Principal Investigator
Patrick Loehrer, M.D.
Indiana University


Backup Contact:

N/A


Location Contact:

Indianapolis, Indiana 46202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 30, 2020

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