Philadelphia, Pennsylvania 19107

  • Migraine


Subjects are scheduled to undergo a Greater Occipital Nerve Block (GONB) as treatment for your chronic daily headache. GONB has been used for many years in the treatment of headaches. The nerve block is done by injecting a liquid drug through the skin of the back of the head to the area of the greater occipital nerve. The nerve runs superficially in this area, therefore the drugs are injected just under the skin. The injected drugs block electrical transmission through the nerve, resulting in reduced head pain. There are treatment options for patients receiving a GONB, however, some clinicians use local anesthetics (lidocaine and /or bupivicaine) alone, and some use local anesthetics with local steroid injection. The purpose of this study is to evaluate whether or not there is an observed difference between these two treatment approaches for GONB. We expect to enroll 60 patients into this research study at Thomas Jefferson University only.


Inclusion Criteria: - Adult patients, age 18-65 inclusive - Patients who have chronic daily headache (15 or more headache days per month) for at least 3 months prior to enrollment in the study. - Headache level should be 5/10 or more at time of GON block. - Patients should have posterior cervical muscle tenderness at time of nerve block. Exclusion Criteria: - Patients who had surgery or any other invasive procedure in the occipital area. - Patients with abnormal sensory findings on examination or any known neurological disease that may affect skin sensation (peripheral neuropathy, multiple sclerosis, stroke, etc). - Patients diagnosed with cluster headache - Patients with skin diseases that may affect skin sensation. - Patients who are cognitively impaired. - Patients with significant psychiatric disorder that may affect their understanding of the study protocol and/or their cooperation with the investigators. - Patients who are pregnant or breast-feeding.



Primary Contact:

Principal Investigator
Stephen D Silberstein, MD
Thomas Jefferson University, Jefferson Headache Center

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19107
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: March 30, 2020

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