Expired Study
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Philadelphia, Pennsylvania 19107


Migraine and the skin sensitivity that accompanies it can go away in minutes after a nerve block, which is a procedure involving an injection of a small amount of a local anesthetic next to a nerve to the skin, causing an area of skin to become numb. We have also noticed that light sensitivity goes away quickly after a nerve block. We would like to see how quickly this happens and how long the benefit of nerve block lasts. We are interested to see if these effects are due to the injection itself or due to the lidocaine. A subject may be asked to participate in this study if a subjects physician has planned for a subject to receive an injection of BOTOX® in the area of the Greater Occipital Nerve (a spinal nerve located at the back of the head) as part of a subjects routine preventive treatment for migraine today.


Inclusion Criteria: - Subjects with episodic or transformed migraine age 18to 80 years old. - Subjects must have unilateral migraine headache and trigeminal distribution brush allodynia at the time of injection. - Subjects must be able to consent or assent to the study. Exclusion Criteria: - Subjects who in their own or in the investigator's opinion are unable to report the severity of four symptoms (pin sharpness to determine efficacy of nerve block, headache severity, photophobia severity and allodynia severity), every 30 seconds for 5 minutes post injection; - Subjects with skull defect, or history of injury to the area of the GON. - Subjects with prior adverse reaction to GON block, lidocaine or marcaine. - Subjects who are pregnant or lactating



Primary Contact:

Principal Investigator
William B Young, MD
Thomas Jefferson University, Jefferson Headache Center

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19107
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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