Expired Study
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Los Angeles, California 90095


Purpose:

It is widely believed that inflammation contributes to the pathogenesis of AD. TNF has been implicated in both AD and neurological inflammation. Anti-TNF therapy is therefore surmised to be of potential benefit for treating AD.


Study summary:

Etanercept, a biologic anti-TNF fusion protein, will be administered weekly or biweekly by perispinal injection to a maximum of 15 study subjects for a period of one month, followed by a 5 month and a 6 month possible study extension, with serial testing of cognition and function monthly.


Criteria:

Inclusion Criteria: - NINCDS-ADRDA Criteria for Alzheimer’s disease - CT or MRI consistent with AD Exclusion Criteria: - active infection - CHF - demyelinating disease - uncontrolled diabetes mellitus - vascular dementia - clinically significant neurologic disease other than AD - Hachinski >4 - history of lymphoma - TBC - wbc<2500 - platelets<100,000 - HCT<30 - pregnancy - premenopausal, fertile not on acceptable birth control - change in neuroactive medication within 4 weeks of study initiation


NCT ID:

NCT00203359


Primary Contact:

Principal Investigator
Edward L Tobinick, MD
unaffiliated (Assistant Clinical Professor of Medicine, David Geffen School of Medicine at UCLA)


Backup Contact:

N/A


Location Contact:

Los Angeles, California 90095
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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