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Minneapolis, Minnesota 55417

  • Kidney Failure


The purpose of this study is to determine if Acetylcysteine is effective in preventing renal failure associated with cardiac surgery

Study summary:

Postoperative renal dysfunction is a predictor of significant morbidity and mortality among patients undergoing cardiac surgery. The mortality associated with coronary artery by-pass surgery increases from 2% to almost 19% in patients with renal failure and approaches 60% in patients who require hemodialysis. Patients with preoperative renal dysfunction referred for coronary artery by pass surgery have an extraordinarily high risk of requiring postoperative dialysis. For example, among those patients with preoperative creatinine >2.5 mg/dL, almost 50% require hemodialysis. Comparison: N-Acetylcysteine is superior to placebo in preventing renal failure after cardiac surgery


Inclusion Criteria: - Pts with baseline chronic kidney disease (eGFR<60 ml/min/1.73m2)undergoing cardiac surgery Exclusion Criteria: - Patients on hemodialysis preoperatively - IV contrast within 4 days prior to surgery - Urgent/emergent surgery - History of renal transplantation



Primary Contact:

Principal Investigator
Selcuk Adabag, MD
Minneapolis Veterans Affairs Medical Center

Backup Contact:


Location Contact:

Minneapolis, Minnesota 55417
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: March 30, 2020

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