New York, New York 10032

  • Epilepsy

Purpose:

The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.


Study summary:

Rolandic epilepsy (RE) is the most common type of childhood epilepsy—affecting more than 50,000 children in the United States—and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy. The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention. Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone. Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.


Criteria:

Inclusion: - typical history of focal seizures - EEG centrotemporal sharp waves - age of onset 3-12 years - no previous epilepsy type (febrile seizures OK) - normal development - normal neurological examination - normal MRI/CT (if done) Exclusion: - only history of secondary generalized seizures - atypical history/semiology - history and EEG inconsistent - abnormal EEG background - very early (<3yrs) or late (>12yrs) onset - global neurodevelopmental deficit - deviant neurodevelopment - structural imaging abnormality


NCT ID:

NCT00282854


Primary Contact:

Principal Investigator
Deb K. Pal, MD, PhD
Associate Research Scientist, Mailman School of Public Health, Columbia University Medical Center

Deb Pal, MD, PhD
Phone: 212 342 1237
Email: dkp28@columbia.edu


Backup Contact:

N/A


Location Contact:

New York, New York 10032
United States

Deb Pal, MD, PhD
Phone: 212-342-1237
Email: dkp28@columbia.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: December 08, 2022

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