New York, New York 10016

  • Lung Cancer

Purpose:

RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer. PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.


Study summary:

OBJECTIVES: - Identify and validate biomarkers for the early detection of lung cancer in individuals at low- or high-risk for smoking-related cancers. - Identify preneoplastic cellular changes and lesions in these patients. OUTLINE: Participants are stratified according to lung cancer risk status (with or without increased risk). Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy. Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy. PROJECTED ACCRUAL: A total of participants will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Screening Cohort - At high- or low-risk for lung cancer - Smoking history ≥ 20 pack years* - With or without workplace exposure to asbestos - NOTE: * Participants with < 20 pack years of smoking are eligible if 50 years of age or older - Rule-Out Lung cancer group - Referred for evaluation of suspicious nodules with 1 of the following diagnoses: - Lung cancer - Nonmalignant nodules (control group) PATIENT CHARACTERISTICS: - Not pregnant - No prior malignancy except nonmelanoma skin cancer PRIOR CONCURRENT THERAPY: - Not specified


NCT ID:

NCT00301119


Primary Contact:

Principal Investigator
James N. Tsay, MD
NYU Langone Health

James N Tsay, MD, MPH
Phone: 212-598-6351
Email: Jun-Chieh.Tsay@nyulangone.org


Backup Contact:

Email: ellen.eylers@nyumc.org
Ellen M Eylers, RN, MSN, MPH
Phone: 212-263-6126


Location Contact:

New York, New York 10016
United States

William N. Rom, MD, MPH
Phone: 212-263-6479
Email: william.rom@med.nyu.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: December 07, 2022

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