Saint Louis, Missouri 63110

  • Cholangiocarcinoma

Purpose:

This is an observational study intended to validate results of a previous study done at the Mayo Clinic. Patients are treated with combination chemotherapy and radiation and maintained on oral Xeloda until they can receive liver transplant. A staging laparotomy is performed before chemoradiation in order to identify patients who will most benefit from the treatment and to improve outcomes.


Criteria:

Inclusion Criteria: 1. Diagnosis of cholangiocarcinoma that has been established preoperatively by at least one of the following criteria: 1. A positive brush cytology or biopsy result obtained at the time of cholangiography; 2. Fluorescence in situ hybridization demonstrating aneuploidy; 3. A serum CA 19-9 value greater than 100 U/mL in the presence of a radiographically characteristic malignant stricture in the absence of cholangitis. 4. Listed for OLT for hilar cholangiocarcinoma 2. Tumor/stricture is above the cystic duct and is unresectable. 3. A suitable candidate for orthotopic liver transplantation as judged by the liver transplant team. All 3 treatment modalities are not needed to confirm eligibility for this registry trial. 4. >/= 18 years of age. 5. Willing and able to provide written informed consent.


NCT ID:

NCT00301379


Primary Contact:

Principal Investigator
William C. Chapman, M.D.
Washington University School of Medicine

William Chapman, MD
Phone: 314-362-7792
Email: chapmanwc@wustl.edu


Backup Contact:

Email: guthriet@wustl.edu
Tracey Guthrie
Phone: 314-747-4404


Location Contact:

Saint Louis, Missouri 63110
United States

William Chapman, MD
Phone: 314-362-7792
Email: chapmanwc@wustl.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: August 03, 2021

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