Saint Louis, Missouri 63119

  • Breast Neoplasms

Purpose:

The main purpose of this study is to compare genetic markers present on tumor cells before and after chemotherapy.


Study summary:

In this study, the investigators propose that persistent disseminated tumor cells (DTC) present after systemic therapy represent a unique subpopulation of all DTC, are predictors of a poor response to systemic therapy and correlate with poor clinical outcome. The investigators hypothesize that systemic therapy-resistant DTC can be identified by their expression of a unique constellation of tumor marker proteins which may be similar to those expressed by breast cancer stem cells. In this research, the investigators' specific aims are : 1) to characterize tumor markers expressed by DTC which are present after systemic therapy, 2) to compare the expression of these markers to that on DTC detected prior to systemic therapy, 3) to correlate expression of the defined tumor markers on DTC with clinical outcome of breast cancer patients to identify those markers that are predictive of disease recurrence, 4) to utilize biomarkers identified in Specific Aims 1 and 2 to isolate purified DTC for further molecular analysis.


Criteria:

Inclusion Criteria: - Recently diagnosed with clinical stage II, III, or IV breast cancer - Planning to undergo neoadjuvant or adjuvant systemic therapy; patients who have already completed neoadjuvant systemic therapy are also eligible - Must be >= 18 years of age - If female, must not be pregnant - Must not have Hepatitis B, C, or HIV - Must be willing and able to sign informed consent document


NCT ID:

NCT00353483


Primary Contact:

Principal Investigator
Rebecca Aft, M.D., Ph.D.
Washington University School of Medicine

Rebecca Aft, MD, PhD
Phone: 314-747-0063
Email: aftr@wustl.edu


Backup Contact:

Email: guthriet@wustl.edu
Tracey Guthrie
Phone: 314-747-4404


Location Contact:

Saint Louis, Missouri 63119
United States

Rebecca Aft, MD, PhD
Phone: 314-747-0063
Email: aftr@wustl.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: August 02, 2021

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