Expired Study
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San Antonio, Texas 78229


Genasense® is currently administered to subjects in clinical studies as a multiple-day continuous intravenous infusion. Subjects are treated on an outpatient basis and carry a pump that delivers the drug through a peripheral or central intravenous line. The route of administration limits the convenience of treatment, and catheter-related complications have been reported. This study is designed to evaluate the pharmacokinetics and safety of G3139 administered by subcutaneuous injection.


Inclusion Criteria: - A Confirmed diagnosis of a solid tumor malignancy, not to include lymphoma, that has failed standard therapy or for which no standard therapy is available. Patients with a history of brain metastasis will be eligible if there is no evidence of cerebral edema or treatment with steroids. - Adequate organ function as determined < 7 days prior to starting study medication - Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2 - At least 3 weeks and recovery from effects of major prior surgery or other therapy including radiation therapy, immunotherapy, cytokine, biological, vaccine and chemotherapy Exclusion Criteria: - Significant medical diesese - History of leptomeningeal disease - Coexisting condition that would require the subject to continue therapy during the treatment phase of the study with a drug known to alter renal function. - Use of any investigational drug within 3 weeks prior to starting study medication - Known hypersensitivity to phosphorothioate-containing oligonucleotides - Pregnancy/Lactation



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Location Contact:

San Antonio, Texas 78229
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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