Expired Study
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Ann Arbor, Michigan 48106


The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Study summary:

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.


Inclusion Criteria: - Adults over age of 18 - Healthy or diagnosis of periodontitis Exclusion Criteria: - Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females



Primary Contact:

Principal Investigator
Yvonne Kapila, DDS, PhD
University of Michigan

Backup Contact:


Location Contact:

Ann Arbor, Michigan 48106
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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