Expired Study
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Rochester, Minnesota 55905


Purpose:

This study is being done to examine the influence of Tiotropium(good or bad)on heart function at rest and during exercise in patients with moderate to severe chronic obstructionve pulmonary disease.


Study summary:

Aim 1. To determine the influence of the long-acting anticholinergic agent Tiotropium (Spiriva) on cardiac function at rest in patients with moderate to severe COPD (FEV1<65% predicted). Measures of cardiac function will include assessment cardiac output as well as echocardiographic measures of right ventricular function, pulmonary vascular pressures, as well as left ventricular function, both systolic and diastolic. Aim 2. To determine the influence of the long-acting anticholinergic agent Tiotropium (Spiriva) on cardiac function during exercise in patients with moderate to severe COPD (FEV1<65% predicted). Exercise will be performed both submaximally in the semi-recumbent position to obtain more detailed cardiac measures as well as in the upright position at a more moderate intensity with measures of cardiac output only. Measures will be made pre/post Tiotropium at matched exercise times along with measures of end expiratory lung volume and esophageal and gastric pressures.


Criteria:

BMI<35. COPD. FEV1 <65 % age predicted. Smoking history of >10 pack years. No daytime oxygen


NCT ID:

NCT00578968


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55905
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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