Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Sacramento, California 95817


It is hypothesized that elevated BNP level correlate with an elevated thoracic impedance/fluid index as measured separately by CRT-D devices and external impedance cardiography. Ultimately, it is also hypothesized that both BNP and thoracic impedance/fluid index measurements are predictive of atrial and ventricular arrhythmias.

Study summary:

The primary aim of this study: 1. To assess the correlation between elevated brain natriuretic peptide levels and elevated thoracic impedance/body fluid index as measured by selective biventricular resynchronization devices and an external impedance cardiography device. 2. Correlate impedance measurements and brain natriuretic levels with occurrence of atrial and ventricular arrhythmias as assessed by interrogation of biventricular devices.


Inclusion Criteria: - Male or female between 18 to 85 years of age. - All patients with biventricular implantable cardio-defibrillators(manufacturer: Medtronic/ model: InSync 7299/7297 or newer). - LVEF <35% - NYHA III/IV - QRS >120 msec - Pt willing and able to sign informed consent. - Conventional heart failure therapy - Clinically stable for six months. Exclusion Criteria: - age less than 18 years of age - age greater than 85 years of age - Creatinine > 2.5 mg/dl. - End stage liver disease complicated by ascites as determined by electronic medical record review. - women who are pregnant, lactating, or plan to become pregnant during the course of the study. - Patients who are heart transplant candidates with expected transplantation within the next six months. - Life expectancy due to non-cardiac cause less than one year. - Anticipated problem with compliance. - Critical valvular stenoses/insufficiencies. - Morbidly obese patients(>300 lbs.) - In patients whom impedance cardiography was not able to be performed because of inability to place sensors. - Planned or known need for revascularization procedures within three months.



Primary Contact:

Principal Investigator
Uma Srivatsa, MD
U C Davis Medical Center

Backup Contact:


Location Contact:

Sacramento, California 95817
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.