Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Indianapolis, Indiana 46202


We will directly test the hypothesis that an initial strategy of lisinopril-based therapy will be more effective than atenolol-based therapy in causing regression of LVH over one year in patients with hemodialysis hypertension despite similar degree of BP reduction.

Study summary:

This is a parallel group, active control, single-center, open-label, randomized controlled trial comparing the safety and efficacy of initial therapy with an ACE inhibitor (lisinopril) vs. beta-blocker therapy (atenolol) each administered three times weekly after dialysis.


Inclusion Criteria: 1. Patients on chronic hemodialysis for > 3 mos. 2. Compliance with hemodialysis treatments as defined by less than one missed dialysis per month 3. Hypertension as diagnosed by ABPM >135/75 mm Hg after participation in the UF Trial, or those on no antihypertensive medications but unwilling to do UF Trial. 4. Presence of LVH on echocardiogram defined as LVMi >104 g/m2 in women and >116 g/m2 in men. 5. Willingness to give informed consent. Exclusion criteria: 1. Vascular event (stroke, myocardial infarction or limb ischemia requiring bypass) within previous six months 2. Noncompliance with hemodialysis treatments 3. Known drug abuse 4. COPD requiring home oxygen 5. Congestive Heart Failure Class III or IV. 6. Body mass index > 40 kg/m2. 7. Known contraindication to atenolol (severe heart failure, bradycardia, bronchial asthma, intolerance or allergy) or lisinopril (cough, pregnancy, intolerance or allergy)



Primary Contact:

Principal Investigator
Rajiv Agarwal, MD
Indiana University

Backup Contact:


Location Contact:

Indianapolis, Indiana 46202
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.