Expired Study
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Boston, Massachusetts 02115


The purpose of this study is to look at the effects of high- and low-salt diets on blood vessel function in healthy subjects.

Study summary:

Healthy volunteers will be enrolled in a dietary sodium intervention to examine impact on vascular function.


Inclusion Criteria: 1. Healthy male, African-American volunteers 2. 18-35 years of age, 3. No personal or first degree relative with hypertension or diabetes, 4. Blood pressure <130/85 mmHg and > 90/60 at the screening visit, 5. Body mass index <30 kg/m2, 6. No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram). Exclusion Criteria: 1. Alcohol intake >2 beverage/night, 2. Smoking, 3. Recreational drug use, 4. Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months, 5. Prescription or herbal medication use, 6. Ischemic changes on resting electrocardiogram, 7. Known hypersensitivity to any of the study drugs, 8. Other active medical problems detected by examination or laboratory testing.



Primary Contact:

Principal Investigator
Rhonda Bentley-Lewis, MD
Massachusetts General Hospital

Backup Contact:


Location Contact:

Boston, Massachusetts 02115
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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