Expired Study
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St. Louis, Missouri 63110


Purpose:

The purpose of this study is to determine if reducing or eliminating radiation treatment to one or both sides of the neck where there is no evidence of cancer can help spare the side effects of radiation treatment for head and neck cancer. In this study, we plan to reduce the amount of radiation treatment received to healthy tissue


Study summary:

The proposed study will prospectively test whether this method of volume reduction can be implemented without a change in the historical institutional locoregional control rate achieved with intensity modulated postoperative radiation therapy (IMPORT). Quality of life measurements via validated instruments will be incorporated to establish correlation of volume reduction with QOL.


Criteria:

Inclusion Criteria: - Patients with pathologically proven tumors of the oral cavity, oropharynx, larynx, or hypopharynx . - Treated with surgical resection with one (or both) side(s) of the neck pathologically N0. - Indication for radiation therapy at the primary site or neck consisting of any of the below characteristics: - Close margin (<= 0.5 cm) - Positive margin - Perineural invasion - Lymphovascular space invasion - Metastatic disease in more than one lymph node - Metastatic disease in more than one lymph node group - Extracapsular extension in any lymph node - Constellation of factors considered to be at risk based on the multi-disciplinary tumor board discussion. - Age >= 18. - Patients must sign study specific, IRB-approved consent form. Exclusion Criteria: - Previous head and neck cancer other than non melanoma skin cancer. - Previous head and neck surgery. - Female patients who are pregnant or nursing.


NCT ID:

NCT00593840


Primary Contact:

Principal Investigator
Wade Thorstad, MD
Washington University School of Medicine


Backup Contact:

N/A


Location Contact:

St. Louis, Missouri 63110
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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