Nashville, Tennessee 37232


Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Study summary:

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12 The specific aims of this research proposal are to: 1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement. 2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.


Inclusion Criteria: - Diagnosis of Normal Pressure Hydrocephalus Exclusion Criteria: - Patients not diagnosed with Normal Pressure Hydrocephalus



Primary Contact:

Principal Investigator
Noel Tulipan, M.D.
Vanderbilt University

Noel Tulipan, M.D.
Phone: 615-322-6875
Email: noel.tulipan@Vanderbilt.Edu

Backup Contact:

Email: mayshan.ghiassi@Vanderbilt.Edu
Mayshan Ghiassi, M.D.
Phone: 615-322-1053

Location Contact:

Nashville, Tennessee 37232
United States

There is no listed contact information for this specific location.

Site Status: Recruiting

Data Source:

Date Processed: February 04, 2019

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