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Scottsdale, Arizona 85260


SGX523 is a drug which acts by blocking the function of an enzyme called MET. MET activity may be important in growth and survival of some types of cancer. This Phase I trial is studying the safety, side effects, and best dose of SGX523 when given to patients with advanced cancer, and how well it inhibits MET activity in tumors.


Inclusion Criteria: - Subject has the ability to understand, able, willing to comply with study procedures and follow up visits, and has provided written consent. - Pathologic evidence of solid tumor. - Failed standard therapy and deemed by the Investigator to be suitable for participation into the trial. - Laboratory values (obtained within 10 days prior to enrollment): ANC: >= 1.5 × 109/L; Platelets: >= 100 × 109/L; Hemoglobin: >= 10.0 g/dL (without transfusions); Bilirubin: within normal range; AST, ALT, and alkaline phosphatase: <= 2.5 x ULN without tumor liver involvement; Serum creatinine: within normal limits; Calculated creatinine clearance: >= 60 mL/min/1.73 m2 for patients with creatinine > Institutional Normal Values; PT/PTT/INR: within normal limits. - Have IHC evidence of phospho-MET expression on tumor material no more than 12 months old. This is a requirement only for entry into the MTD dose expansion phase. - Have no residual toxic effects of previous therapy, and undergo a washout period of at least 5 half-lives from the time of administration of the previous therapy. Exclusion Criteria: - Pregnant, lactating, or may become pregnant. - Cardiac disease requiring medical therapy. - Have had a major surgery within 4 weeks prior to Day 1 of the study - Have an active, uncontrolled bacterial, viral, or fungal infection that requires ongoing systemic therapy. - Have a known active infection with HIV, hepatitis B or C. - Have psychiatric or seizure disorders that would require therapy or interfere with study participation. - Have other severe concurrent nonmalignant disease that could compromise protocol objectives, including malabsorptive conditions. - Patients receiving prohibited medications as listed in Appendix E, including drugs categorized as strong inhibitors of CYP3A4 and A5 and drugs known to have a high potential risk of liver toxicity. - Have known allergy to SGX523 formulation or its excipients (croscarmellose sodium, lactose monohydrate and magnesium stereate). - Patients receiving anti-coagulant therapy.



Primary Contact:

Principal Investigator
Michael Gordon, MD
Premier Onocology, Arizona

Backup Contact:


Location Contact:

Scottsdale, Arizona 85260
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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