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Chicago, Illinois 60637


Purpose:

The purpose of this study is to describe the length of time and extent of blood pressure response to minoxidil and hydralazine among cancer patients with difficult-to-treat vascular endothelial growth factor (VEGF) inhibitor treatment induced hypertension.


Criteria:

Inclusion Criteria: - Ongoing treatment for malignancy by at the University of Chicago with any agent with recognized, specific inhibition of VEGF, VEGF-receptors, or downstream signaling molecules with the specific intention of inhibiting signaling of this pathway. These agents include but are not limited to: bevacizumab (Avastin™), sorafenib (Nexavar™), sunitinib (Sutent™), axitinib (AG-013736), and AZD 2171. - Treatment of hypertension with at least 2 or more anti-hypertensive medications with blood pressure remaining greater than 140/90 mmHg. - Stable management of other toxicities from the cancer treatments - Expected to continue current cancer treatments for at least 4 weeks - 18 years and older - Ability to understand and the willingness to sign a written informed consent document prior to any study specific procedures. Exclusion Criteria: - Concurrent use of hematopoietic supportive treatment with erythropoietin or congeners. - Current uncontrolled toxicities due to the cancer treatments. - Patients having known contraindications to hydralazine or minoxidil therapy. - Any readings of systolic blood pressure >200 mmHg or diastolic blood pressure >120 mmHg in the four (4) weeks prior to screening. - Use of either minoxidil or hydralazine in the six (6) months prior to screening.


NCT ID:

NCT00607477


Primary Contact:

Principal Investigator
Michael Maitland, M.D.
University of Chicago


Backup Contact:

N/A


Location Contact:

Chicago, Illinois 60637
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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