Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Baltimore, Maryland 21201


Elevations of plasma cortisol, a stress hormone, during prior episodes of low blood sugar (hypoglycemia) appear to be responsible for the deficient responses during subsequent hypoglycemia. Our specific aim is to determine if dehydroepiandrosterone (DHEA), a hormone with anti-corticosteroid actions, can prevent hypoglycemia associated autonomic failure in type 1 diabetic volunteers.

Study summary:

DHEA is the acronym for dehydroepiandrosterone, a steroid hormone produced naturally from cholesterol in the adrenal glands of males and females. It is also sold as an over-the-counter dietary supplement, and seems to have anticorticosteroid effects. DHEA antagonizes the effects of corticosterone on hippocampal function in rats and reduces responses to neural stress in mice. In our lab we have found that administration of the DHEA to rats during antecedent hypoglycemia, preserves counter-regulatory responses to subsequent hypoglycemia. The purpose of this study is to determine if the same response occurs in humans.


Inclusion Criteria: - 28 (14 males, 14 females) Healthy volunteers aged 18-45 yr. - 28 (14 males, 14 females) Type 1 diabetic patients aged 18-45 yr. - HbA1c < 11.0% - Has been diagnosed Type 1 DM - No major diabetic tissue complications (i.e. history of retinopathy, neuropathy, stasis ulcers, etc) - Body mass index < 40kg/m-2 Exclusion Criteria: - pregnancy Medical history- - Hepatic Failure/Jaundice - Renal Failure - Acute Cerebrovascular/ Neurological deficit Physical Exam- - Pneumonia - Fever greater than 38.0 C - Blood labs according to protocol



Primary Contact:

Principal Investigator
Stephen N. Davis, MD
University of Maryland, Baltimore

Backup Contact:


Location Contact:

Baltimore, Maryland 21201
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.