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Baton Rouge, Louisiana 70808


The study is designed to determine the effect of high physical activity level vs. low physical activity level on the adaptation to a high fat diet.

Study summary:

A high fat diet is linked to weight gain and obesity. An adjustment to the acute exposure to high fat diet is not abrupt and takes time. In a previous study from our laboratory, it has been shown that high level of physical activity can accelerate the adaptation to a high fat diet by increasing fat oxidation. In this study we will determine the mechanism involved in this adjustment. Our hypotheses are: 1. High fat diets decrease skeletal muscle glucose metabolism and decrease mitochondrial biogenesis through the upregulation of PDK4 and downregulation of PGC1α; increased physical activity will prevent these deleterious effects. 2. A high fat diet will increase hepatic and skeletal muscle lipid; increased physical activity will prevent these deleterious effects. 3. These effects are more pronounced in individuals with a low mitochondrial content


Inclusion Criteria: - Both genders and all races will be invited to participate - BMI > 19 and < 35 kg/m2 - Age 18-35 - Women will be asked to participate in the follicular phase of the menstrual cycle as determined by menstrual history and a negative pregnancy test will be recorded prior to participation - Willing and able to walk on a treadmill at a pace of 3 mph at 3%grade for 3-4 hours/day for 3 consecutive days - Willing to eat only and all foods provided by Pennington for 9 days on 2 occasions (18 days) - Willing to stop alcohol consumption for the duration of the study - Able come to Pennington for meals and tests for 20 days 12 of these inpatient. Exclusion Criteria: - Significant renal, hepatic, endocrine, pulmonary, cardiac or hematological disease (for the consent form you will have to use kidney, liver, etc ) - You abuse alcohol or illegal drugs or are unable to avoid alcohol or caffeine prior to testing - Smokers - Unable or unlikely to eat all and only food provided by the PBRC metabolic kitchen. - Pregnant or planning to become pregnant - Corticosteroid use in previous two months - Chronic use of anti-diabetic, anti-hypertensive, or other medications known to affect fat metabolism - Use of Depo-Provera, hormone implants or estrogen replacement therapy - Irregular menstrual cycles - Post-menopausal women - Weight gain or loss of > 3kg in the last 6 months - Unable or unwilling to perform treadmill walking at the required speed and incline to achieve 1.8*RMR - History or family history of blood clots deep vein thrombosis or pulmonary embolism) - Poor circulation, bypass operation on legs, blood coagulation disorders, diagnosed peripheral arterial or vascular disease, cramping pain in your muscle during exercise or nerve damage in your legs. - You had major surgery on the abdomen, pelvis or legs within previous 3 months. - You have cancer - You have rheumatoid disease/ walking or joint problems - You are claustrophobic - You are depressed or have an eating disorder - You demonstrate a style of interpersonal relationships that would inhibit successful completion of the study For the MRS / MRI, the following exclusion criteria apply: - Individuals who have a heart pacemaker, defibrillator, or non-removable hearing aid - Individuals with any clips or metal plates in their head - Individuals who have any artificial limbs or prosthetic devices - Individuals who were ever injured by a metallic foreign body which was not removed - Individuals with bridgework held in place by magnets



Primary Contact:

Principal Investigator
Steven Smith
Pennington Biomedical Research Center

Backup Contact:


Location Contact:

Baton Rouge, Louisiana 70808
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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