Expired Study
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West Haven, Connecticut 06516


This study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of NMDA antagonism as evidenced by event-related potentials (ERPs) in healthy humans.


Inclusion Criteria: - Ages of 21-45 years from all ethnic backgrounds. - Male or female. - Written informed consent. Exclusion criteria - DSM-IV diagnosis for a psychotic, depressive or anxiety disorder. - A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox, Urine pregnancy test) . - History of severe allergies or multiple adverse drug reactions. - Any medication that in the opinion of the PI could interfere with either the safety of the study and/or the outcome measures. - Any other conditions which in the opinion of the investigator would preclude participation in the study. - History of major psychiatric disorder in first degree relatives. - Current substance abuse/dependency determined by urine toxicology. - Current treatment with medications with psychotropic effects. - Treatment with benzodiazepines within one week prior to testing. - Current pregnancy, unsatisfactory birth control method report for females. - Education < 10th grade. - IQ < 70, MR as determined by Wechsler Abbreviated Scale of Intelligence. - Non-English speaking.



Primary Contact:

Principal Investigator
Handan Gunduz-Bruce, M.D.
Yale School of Medicine

Backup Contact:


Location Contact:

West Haven, Connecticut 06516
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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