Expired Study
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Salt Lake City, Utah 84106


Purpose:

This study will evaluate the addition of enzastaurin to 5-FU(5-fluorouracil)/LV (leucovorin) plus bevacizumab in the maintenance of best response obtained with 6 cycles of first-line therapy consisting of FOLFOX (5-FU/LV + oxaliplatin) or FOLFIRI(5-FU/LV + irinotecan), plus bevacizumab in patients with Metastatic Colorectal Cancer.


Criteria:

Inclusion Criteria: - Histologic diagnosis of locally advanced or metastatic CRC that is not curable. The histology types to be included are adenocarcinoma, mucinous adenocarcinoma, signet ring, and undifferentiated. Patients with neuroendocrine carcinomas will be excluded. - Received 6 cycles (3 months [12 weeks]) of first-line therapy with FOLFOX or FOLFIRI, plus bevacizumab for metastatic CRC. Patients have received at least 5 cycles with bevacizumab. Patients who received 6 cycles of first-line therapy with FOLFOX or FOLFIRI, plus bevacizumab for recurrent CRC that has relapsed at least 12 months after completion of adjuvant therapy will also be included. All standard FOLFOX ( or FOLFIRI) regimens given on a biweekly schedule will be permitted; however, 21-day regimens will not be allowed. - No more than 4 weeks may pass between the end of first-line therapy (that is, Day 14 of Cycle 6) and randomization. - Documented evidence of tumor response of CR, PR, or SD by computed tomography (CT) scan or magnetic resonance imaging (MRI). Confirmation of response is not required. Exclusion Criteria: - Are unable to swallow tablets. - Have received treatment within the last 30 days with a drug that has not received regulatory approval for any indication at the time of study entry. - Have known central nervous system metastases. - Are receiving concurrent administration of any other antitumor therapy. - Patients who have significant heart, liver, kidney, or psychiatric disease or have an active infection


NCT ID:

NCT00612586


Primary Contact:

Study Director
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company


Backup Contact:

N/A


Location Contact:

Salt Lake City, Utah 84106
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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