Expired Study
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Lone Tree, Colorado 80124


This prospective randomized trial evaluates whether one can predict which infertile women with endometriosis who are candidates for in vitro fertilization will benefit from prolonged therapy with a GnRH agonist by the determination of the absence of endometrial expression of the integrin, alpha v, beta 3 vitronectin. This is a prospective randomized trial in which all patients will undergo endometrial biopsy prior to initiation of ovarian stimulation for in vitro fertilization and then undergo randomization to a three month course of a depot preparation of the GnRH agonist leuprolide acetate in depot suspension prior to ovarian stimulation or standard therapy. prio

Study summary:

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Inclusion Criteria: - Infertility - Surgical diagnosis of endometriosis - Normal ovarian reserve testing - Regular menses Exclusion Criteria: - Irregular menses - Undiagnosed abnormal uterine bleeding - Pregnancy - Prior adverse reaction to any GnRH agonist - Ovarian cystic or solid mass > 3cm in mean diameter at study entry - Use of a depot preparation of a GnRh agonist or any hormonal therapy for endometriosis within 6 months of study entry - Current hepatic, renal, hematologic or psychiatric disorder



Primary Contact:

Principal Investigator
Eric S Surrey, M.D.
Colorado Center for Reproductive Medicine

Backup Contact:


Location Contact:

Lone Tree, Colorado 80124
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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