Expired Study
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Los Angeles, California 90095


Pulmonary Arterial Hypertension (PAH) in the setting of Idiopathic Pulmonary Fibrosis(IPF)is a risk factor for morbidity and mortality in the peri-lung transplant(LT) setting. Currently there is no significant data to support the use of pulmonary vasodilators for PAH in the setting of interstitial lung disease such as IPF. The majority of IPF patients have PAH either at rest or during exercise. The study hypothesis is that sildenafil may improve morbidity and mortality in the peri-LT setting in both IPF cohorts with either resting or exercise PAH.

Study summary:

The purpose of this study is to evaluate the use of sildenafil in patients with pulmonary fibrosis and PH being considered for lung transplantation. We hypothesize that not only will sildenafil improve functionality and QOL in the pre-transplant setting but it may also improve primary graft dysfunction after lung transplantation.


Inclusion Criteria: - Patients with Idiopathic Pulmonary Fibrosis referred for lung transplantation at our medical center - Minimal 6 minute walk distance of 50 meters; must be able to conduct supine exercise during heart catheterization Exclusion Criteria: - Non ambulatory - Prior adverse reaction/allergy to sildenafil or other PDE-5 Inhibitors - Any other pulmonary vasodilator within one month of enrollment



Primary Contact:

Study Director
Rajan Saggar, MD
David Geffen School of Medicine, UCLA

Backup Contact:


Location Contact:

Los Angeles, California 90095
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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