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Winston-Salem, North Carolina 27157


The Women's Health Initiative Study of Cognitive Aging (WHISCA) is a two-armed, randomized, placebo controlled, clinical trial designed to assess the efficacy of postmenopausal hormone therapy (HT) on age related changes in specific cognitive functions.

Study summary:

WHISCA is an ancillary study to the Women's Health Initiative (WHI) and the WHI Memory Study (WHIMS) and has enrolled 2303 women aged 66 to 84 years who did not meet the criteria for dementia. WHISCA is investigating the effects of hormone therapy on rates of change over time in memory, other aspects of cognition (language, attention, spatial ability), motor function, and mood. Objectives - Does HT protect against age-associated memory and cognitive longitudinal decline in women age 65 and older? - What is the rate of change in memory and other cognitive abilities in women receiving HT compared to women receiving placebo? - Does the addition of progesterone to HT modify the effects of estrogen on memory and other cognitive abilities?


Inclusion Criteria: - Enrolled in WHIMS - At least 65 years old - Not diagnosed with dementia Exclusion Criteria: - Women younger than 65 years of age - Have dementia - not enrolled in WHIMS



Primary Contact:

Principal Investigator
Sally Shumaker, PhD
Wake Forest University Health Sciences

Backup Contact:


Location Contact:

Winston-Salem, North Carolina 27157
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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