Expired Study
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Salt Lake City, Utah 84132


Several human genes affect how medications are metabolized by the body. It is believed that knowledge of variations of these genes can help health care providers better manage an anticoagulation medicine called warfarin (Coumadin®)and as a result decrease patient problems with bleeding or the development of blood clots. This study is designed to evaluate if genetic testing can improve warfarin initiation better than usual care.


Inclusion Criteria: - Participants will be otherwise healthy adults (≥ 18 years of age) who are planning total hip or knee replacement or revision surgery at the University of Utah Hospital, and schedule a pre-operative office visit at the University of Utah Orthopaedic Center. Exclusion Criteria: - Blood transfusion in previous two weeks - Participant is already taking warfarin - Pre-operative INR > 4.0 - Pre-operative bilirubin > 2.4 mg/dL - Current active cancer diagnosis with ongoing treatment - Concomitant medications known to exert a major interaction with warfarin such as septra, metronidazole, tramadol, amiodarone, ciprofloxacin, or cimetidine.



Primary Contact:

Principal Investigator
Gwen McMillin, PhD
ARUP Laboratories

Backup Contact:


Location Contact:

Salt Lake City, Utah 84132
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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