Expired Study
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Baltimore, Maryland 21201


This is an unblinded pilot study comparing (against a randomized control day without water immersion) the diuretic and natriuretic effects of water immersion in patients with right heart failure.

Study summary:

Patients will be immersed in a tub for 3 hours (on one day) and neurohormones will be obtained before and after immersion. Urine will be collected for quantification and evaluation of sodium concentration.


Inclusion Criteria: - Patients must have right sided failure secondary to right ventricular dysfunction, pulmonary hypertension, or tricuspid regurgitation - Age greater than 18 years of age - Right heart catheterization within the last year to rule out left-sided failure. - Evidence of fluid overload as indicated by 2 or more of the following: 1.) 2+ or more pitting edema of the lower extremities, 2.) scrotal or penile edema, 3.) JVP greater than or equal to 10 cm, 4.) abdominal ascites Exclusion Criteria: - Pulmonary capillary wedge pressure above 16 mmHg or history of elevated left ventricular filling pressures. - Serum creatinine > 2.0 - Current use of an angiotensin I converting enzyme inhibitor or angiotensin receptor blocker will preclude participation in the RAS neurohormone portion of the study.



Primary Contact:

Principal Investigator
Stephen Gottlieb, MD
University of Maryland

Backup Contact:


Location Contact:

Baltimore, Maryland 21201
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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