Expired Study
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Albuquerque, New Mexico 87102


Purpose:

Hypothesis: one-dose pamidronate will prevent post-operative bone loss in children at risk for low bone density Plan: children with chronic disease such as CP, spina bifida, etc. will be recruited pre operatively and studied with DXA scan. After surgery, children will be randomized to receive either pamidronate or saline. Repeat DXA scan will determine bone lost after end of immobilization or nonweightbearing.


Study summary:

Children at risk for post operative bone loss will be studied with preoperative DXA scan of spine and distal femora Preoperative screening with standard labs electrolytes, Ca++, PO4, creatinine, Vit D Following surgery of hip(s) or lower extremities, randomization into treatment with low dose IV pamidronate (one dose) v placebo group Repeat DXA scan after end of immobilization or non-weightbearing


Criteria:

Inclusion Criteria: - chronic condition predisposing to low bone density, such as cerebral palsy, osteogenesis imperfecta - lower extremity surgery proposed that will require post op nonweightbearing, casted or not, for a minimum of 4 weeks Exclusion Criteria: - creatinine >1.2 - prior bisphosphonate exposure - orthopaedic implants in distal femoral precluding DXA scan - inability to cooperate with DXA scan


NCT ID:

NCT00655681


Primary Contact:

Principal Investigator
Elizabeth A Szalay, MD
University of New Mexico Carrie Tingley Hospital


Backup Contact:

N/A


Location Contact:

Albuquerque, New Mexico 87102
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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