Expired Study
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Madison, Wisconsin 53792


This is an open-label study to determine the highest dose of MKC-1 that may be administered daily on a continuous basis for patients with advanced or refractory solid tumors.


Inclusion Criteria: - Have histologically confirmed malignancy that is metastatic or unresectable and for which standard curative measures do not exist or are no longer effective. - Age greater than or equal to 18 years. - ECOG performance status ≤1 - ANC greater than or equal to 1,500/mm3; - Platelets greater than or equal to 100,000/mm3 - creatinine ≤1.5 times institutional upper limit of normal (ULN) - T Bili within normal limits; - AST and ALT less than or equal to 2.5 times ULN; and - albumin greater than or equal to 3.0 g/dL - have measurable disease by RECIST, radiographically evaluable disease, or detectable disease - women of child-bearing potential and men must agree to use adequate contraception - Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: - Have previously received MKC-1. - Have received radiation to greater than 25% of the bone marrow. - Have had anti-cancer therapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier. - Are concurrently receiving any other investigational agents while on study. - Have known brain metastases - Have any condition that impairs the ability to swallow and retain MKC-1 capsules. - Uncontrolled intercurrent illness - Are pregnant or breastfeeding - HIV-positive patients - Patients with uncontrolled diabetes



Primary Contact:

Principal Investigator
Glenn Liu, MD
U. of Wisconsin

Backup Contact:


Location Contact:

Madison, Wisconsin 53792
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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