Expired Study
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Chicago, Illinois 60611


The purpose of this study is to determine if providing free-of-charge access to a group-based lifestyle intervention delivered in partnership with the community is cost-effective for the prevention of type 2 diabetes.

Study summary:

Randomized controlled trials have shown that modest lifestyle changes can prevent or delay the onset of diabetes in adults with pre-diabetes. Unfortunately, despite the increasing prevalence of pre-diabetes and diabetes in all facets of the population, intervention programs needed to achieve these goals are costly and remain unavailable in most clinical settings. Over the past 3 years, we have demonstrated the feasibility of training community instructors to deliver a group-based adaptation of the Diabetes Prevention Program (DPP) lifestyle intervention. In this pilot research, this new delivery model achieves a level of weight reduction that was associated with diabetes prevention and improved cardiometabolic risk factor control in the DPP. This new, large-scale randomized effectiveness trial is designed to evaluate the costs and effectiveness of a partnered approach to identify adults with pre-diabetes in primary care settings, deliver brief advice for diabetes prevention, and provide access to a group-based adaptation of the DPP lifestyle intervention offered by the community. This study will compare costs and outcomes to a standard care, brief clinical counseling approach delivered by Registered Dietitians.


Inclusion Criteria: - 18 years of age or older - Body-mass index of 24 kg/m2 or greater - Fasting Blood Glucose 100 - 125 mg/dl, OR 2-hour Post-challenge Capillary Glucose 140 - 199 mg/dl Exclusion Criteria: - Cancer requiring treatment in the past 5 years - Uncontrolled hypertension: systolic blood pressure >180 mmHg or diastolic blood pressure >105 mmHg - Heart attack, stroke, or transient ischemic attack in the past 6 months, - Chronic obstructive airways disease or asthma requiring home oxygen - Other chronic disease or condition, such as advanced arthritis, that could limit ability to become physically active or limit life span to <5 years - Pregnancy - Existing diagnosis of diabetes mellitus - Fasting capillary blood glucose > 125 mg/dl - 2-hour post-challenge capillary blood glucose > 199 mg/dl - History of anti-diabetic medication use (oral agents or insulin) except during gestational diabetes - Self-report of a medication known to lead to hyperglycemia (oral steroids, antipsychotics, anti-epileptics) - Self-report of disease associated with disordered glucose metabolism: Cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis



Primary Contact:

Principal Investigator
Ronald T Ackermann, MD, MPH
Northwestern University School of Medicine

Backup Contact:


Location Contact:

Chicago, Illinois 60611
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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