Boston, Massachusetts 02115


To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.


Inclusion Criteria: - Subjects with >= 70% carotid stenosis (unilateral or bilateral) who are scheduled to undergo elective carotid endarterectomy - Age >= 18 years - Agreement of the operating surgeon for patient to participate Exclusion Criteria: - Surgery scheduled < 14 days after randomization - Pregnancy - ALT, GGT > 3x upper limit of normal (ULN) - Creatinine > 3.5 mg/dL - Prior intolerance to statins - Reluctance to add or change dosage of statin therapy during study



Primary Contact:

Principal Investigator
Anju Nohria, MD
Brigham and Women's Hospital

Anju Nohria, MD
Phone: 617 525-6852

Backup Contact:

Jeanne Doyle, BS, RN. BC
Phone: 617 525-7055

Location Contact:

Boston, Massachusetts 02115
United States

Anju Nohria, MD
Phone: 617-525-6852

Site Status: Recruiting

Data Source:

Date Processed: February 04, 2019

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