Expired Study
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Rochester, Minnesota 55905


RATIONALE: Gathering information about allergies to metals may help doctors learn whether having an allergy to metal used in dental work increases the risk of developing oral cancer. PURPOSE: This clinical trial is studying contact allergies to dental metal as a possible risk factor for oral cancer.

Study summary:

OBJECTIVES: - Identify the relationship between intraoral metal contact allergy and epithelial carcinogenesis in patients with newly or previously diagnosed intraoral squamous cell carcinoma. - Compare the prevalence of metal contact allergy in these patients with control data from other existing study populations. OUTLINE: This is a multicenter study. - Participants undergo metal patch testing using 27 metals* commonly used in dental repairs that are part of the Mayo metal series. Metal patches are applied to the patient's back for 3 days and the back is read on days 3 and 5. Relevant patient data obtained from their medical and dental history, physical exam, laboratory values and treatment are documented. NOTE: *Healthy volunteers (control) undergo metal patch testing using 8 metals most commonly positive for contact allergens.


DISEASE CHARACTERISTICS: - Meets 1 of the following criteria: - Newly or previously diagnosed oral squamous cell carcinoma - Recruited from the otorhinolaryngology departments of Mayo Clinic Rochester and Mayo Clinic Arizona - Healthy volunteer (control) - No history of intraoral squamous cell carcinoma - Employed at Mayo Clinic Rochester or Mayo Clinic Arizona PATIENT CHARACTERISTICS: - No immunosuppression - No other conditions that interfere with patch testing PRIOR CONCURRENT THERAPY: - Not specified



Primary Contact:

Study Chair
James A. Yiannias, MD
Mayo Clinic

Backup Contact:


Location Contact:

Rochester, Minnesota 55905
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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