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La Jolla, California 92037


The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function.

Study summary:

Increased amygdala and insula activity have been implicated in neurobiological models of anxiety. Using fMRI, the anxiolytic medication, lorazepam, has previously been found to decrease activation in these areas during the processing of emotional stimuli. This study aims to replicate those results but by using a different medication, alprazolam. An eventual aim of this study, in combination with future studies, is to evaluate the utility of fMRI as a tool to identify anxiolytic function in both established and novel compounds that may be used to treat anxiety.


Inclusion Criteria: - Male, or female (not pregnant or intending to become pregnant during the study) - Between the ages of 18-30. - In good general health. - No specific contraindications to the drug being administered Exclusion Criteria: - Subjects with a history of DSM-IV depressive disorder, psychotic disorder, anxiety disorder - Subjects who meet criteria for substance abuse or dependence within the last 6 months - Subjects with an positive urine screen for illicit drugs - having clinically significant abnormal laboratory, ECG or physical examination findings not resolved by the baseline visit - Patients who have taken psychotropic drugs or antidepressants (including monoamine oxidase inhibitors, MAOI's) within the last year - subject is left-handed. - The subject suffers from claustrophobia, or phobia for injections or blood. - Magnetic Resonance Imaging related exclusion criteria: cardiac pacemaker, metal fragments in eyes/skin/body (shrapnel), subjects who have ever been a metal worker/welder; history of eye surgery/eyes washed out because of metal, aortic/aneurysm clips, prosthesis, by-pass surgery/coronary artery clips, hearing aid, heart valve replacement, subjects who are in the first trimester of pregnancy, subjects with an I.U.D. (birth control device), a shunt (ventricular or spinal), electrodes, metal plates/pins/screws/wires, or neuro/bio-stimulators (TENS unit).



Primary Contact:

Principal Investigator
Murray B Stein, MD, MPH
University of California, San Diego

Backup Contact:


Location Contact:

La Jolla, California 92037
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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