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Atlanta, Georgia 30303


Although a large number of obese patients develop high blood pressure, the cause is unknown. The purpose of this study is to look at the effect of high fatty acids (a type of fat) in the development of high blood pressure in obese people.

Study summary:

Recent studies indicate that increased levels of a circulating fat (free fatty acids or FFAs) increases blood pressure, impairs endothelial (vascular) function, and increases inflammatory markers in subjects with and without diabetes. The effects of FFA on blood pressure and vasculature have not been fully investigated. A group of 12 obese nondiabetic, normotensive subjects will be admitted to the Grady Clinical Research Center (GCRC) on separate 4 occasions. Research subjects will receive, in random order, a 8-hour intravenous (IV) infusion of Intralipid 20% at 40 mL/h (a fat solution), 8-hour IV infusion of normal saline at 40 mL/h, 8-hour IV infusion of dextrose (sugar) 10% at 40 mL/h, and a 8-hour intravenous (IV) infusion combination of Intralipid 20% and dextrose 10% at 40mL/h.


Inclusion Criteria: - Males or females - Obese subjects (body mass index (BMI) ≥ 30 kg/m^2) - 18 and 65 years - Blood pressure reading < 140/80 mm Hg and no prior history of hypertension Exclusion Criteria: - History of diabetes mellitus - History of hypertension - Fasting triglyceride levels > 250 mg/dL - Liver disease (ALT 2.5x > upper limit of normal) - Serum creatinine ≥1.5 mg/dL - Smokers, drug or alcohol abuse - Mental condition rendering the subject unable to understand the scope and possible consequences of the study - Female subjects who are pregnant or breast feeding



Primary Contact:

Principal Investigator
Guillermo Umpierrez, MD
Emory University

Backup Contact:


Location Contact:

Atlanta, Georgia 30303
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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