San Francisco, California 94143


Purpose:

The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical Outcomes Study 36-item Short Form (SF-36) and the Sino-Nasal Outcomes Study - 20 Questions (SNOT-20).


Study summary:

The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical Outcomes Study 36-item Short Form (SF-36) and the Sino-Nasal Outcomes Study - 20 Questions (SNOT-20). The study design involves case control Polymerase Chain reaction (PCR) analysis of nasal mucosal swabs, saliva swabs, blood serum, and home vacuum cleaner bags in patients with sinusitis and normal controls. The hypothesis is that the quantity and type of fungal DNA present in the nose and home environment are directly correlated with quality of life. Our research aims to both quantify the amount of fungi present in the nasal mucosa as well as to measure the severity of the patient's chronic rhinosinusitis (CRS) as a function of SNOT-20 and SF-36 outcomes questionnaires. We hypothesize that the amount and type of fungi present in the nose and home environment will correlate with the severity of the patients' symptoms of CRS.


Criteria:

Inclusion Criteria: - Subjects with no sinus disease and subjects with chronic rhinosinusitis. Exclusion Criteria: - Immunocompromise - Pregnancy - Minors


NCT ID:

NCT00739921


Primary Contact:

Principal Investigator
Andrew Murr, MD
University of California, San Francisco

Maria Mogannam
Phone: 415-353-2870
Email: maria.mogannam@ucsf.edu


Backup Contact:

Email: ahmurr@ohns.ucsf.edu
Andrew Murr, MD
Phone: 415-353-2870


Location Contact:

San Francisco, California 94143
United States

Maria Mogannan
Phone: 415-353-2870
Email: maria.mogannan@ucsf.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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