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Hershey, Pennsylvania 17033


The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2) rapidly alters glucose tolerance in healthy volunteers. These questions will be answered by having volunteers undergo two glucose tolerance tests in a crossover study design.


Inclusion Criteria: - Healthy Volunteer - Body Mass Index of 18.5-25 kilograms per square meter - Must be able to swallow tablets - Able to give informed consent Exclusion Criteria: - Any DSM-IV TR Axis I psychiatric disorder (except nicotine dependence) - Presence of any medical disorder that may confound the assessment of relevant biologic measures, including: significant organ system dysfunction, metabolic diseases, type 1 diabetes mellitus, type 2 diabetes mellitus, pregnancy, endocrine disease, coagulopathy, clinically significant anemia, or acute infection - Subjects who have taken any antipsychotic medication within the last 6 months - Personal or family history of seizures and/or cardiac arrhythmias



Primary Contact:

Study Director
Ravi Singareddy, M.D.
Penn State College of Medicine, Penn State Milton S. Hershey Medical Center

Backup Contact:


Location Contact:

Hershey, Pennsylvania 17033
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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