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Minneapolis, Minnesota 55455


This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function. Our hypothesis was that vitamin D supplementation to normal levels in patients with impaired fasting glucose will result in improved insulin sensitivity and improved beta cell function.

Study summary:

A modified frequently sampled intravenous glucose tolerance (mFSIGT) test was used. On day 0, baseline 22 time point mFSIGT was performed. Subjects were then treated with cholecalciferol (vitamin D3) supplementation - 10,000 IU/day - for 28 consecutive days. mFSIGT was then repeated measuring glucose, insulin and c-peptide at all time points. 25-OH vitamin D, PTH, and calcium were also measured at time point 0 pre and post vitamin D supplementation. Data was analyzed using the Bergman/Boston minimal model for insulin homeostasis with MinMod Millennium software.


Inclusion Criteria: - Impaired fasting glucose - Adult, age between 18 and 65 - Serum vitamin D level below 30 ng/mL Exclusion Criteria: - History of nephrolithiasis - Any medications that can effect insulin sensitivity or beta cell function (i.e. antipsychotics, metformin) - Pregnancy - Liver disease - Renal disease



Primary Contact:

Study Director
Cary Mariash, MD
University of Minnesota - Clinical and Translational Science Institute

Backup Contact:


Location Contact:

Minneapolis, Minnesota 55455
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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