Birmingham, Alabama 35294


Purpose:

The purpose of this study is to determine if atorvastatin (Lipitor) reduces the occurence of abnormal heart rhythm (atrial arrhythmia) following non cardiac thoracic surgery.


Study summary:

The incidence of atrial arrhythmia after thoracic, non-cardiac procedures is exceedingly common and has been reported to occur in between 10-39% of patients. It has been shown to increase majority morbidity and also delay hospital discharge. Recent studies suggest that one week of pre-operative atorvastatin may reduce the incidence of post-operative atrial arrhythmia in patients who undergo cardiac surgery and a multi-institutional study is currently underway to further examine this concept. However, there are no published prospective randomized studies to date that have evaluated the effectiveness of atorvastatin to reduce atrial arrhythmia in patients who undergo thoracic, non-cardiac operations such as esophagectomy or pulmonary resection. The object of this study is to determine if atorvastatin reduces the incidence of atrial arrhythmia (atrial fibrillation or flutter) following non-cardiac thoracic surgery, specifically pulmonary resections.


Criteria:

Inclusion Criteria: - Patients scheduled for elective non-cardiac thoracic surgery requiring thoracotomy for resection Exclusion Criteria: - Past medical history of pacemaker implantation - Pregnancy or lactating - History of Atrial arrhythmia within the past year - Elevated liver enzymes pre-operatively - Past medical history of any liver disease or history of liver transplantation - Use of statins or any anti-arrhythmics (including beta-blockers, calcium channel blockers, digoxin) within 3 months prior to surgery - Pre-op EKG showing atrial arrhythmia


NCT ID:

NCT00756886


Primary Contact:

Principal Investigator
Robert J Cerfolio, MD
University of Alabama at Birmingham, Department of Surgery

Ayesha S Bryant, MD
Phone: 205 934-5937
Email: abryant@uab.edu


Backup Contact:

Email: arawlins@uab.edu
Ashlee B Rawlins, BS
Phone: 205 996-7361


Location Contact:

Birmingham, Alabama 35294
United States



There is no listed contact information for this specific location.

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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