Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Boston, Massachusetts 02115


Purpose:

This study will determine whether or not saphenous vein [arterial] bypass grafts in the leg relax in response to increases in blood flow.


Study summary:

Subjects who have undergone saphenous vein [arterial] bypass grafts from the femoral to above-knee popliteal artery will undergo ultrasound imaging at rest, and again after 5 minutes of blood pressure cuff occlusion of the calf. (at 1 minute and 15 minutes) Subjects will then be given sub-lingual nitroglycerin, and repeat ultrasound will be performed 3 minutes later. Following 10 minutes of rest, subjects will be given intravenous L-NMMA, a specific nitric oxide inhibitor, to help determine the responsible agent of the vein graft flow mediated dilation.


Criteria:

Inclusion Criteria: - Adults who have undergone femoral artery to above-knee popliteal artery saphenous vein bypass grafts Exclusion Criteria: - Amputation beyond the toes - Critical limb ischemia defined as rest pain, non-healing ulceration or gangrene - Pregnancy


NCT ID:

NCT00759707


Primary Contact:

Principal Investigator
Joshua A. Beckman, M.D.
Brigham and Women's Hospital


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02115
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.