Expired Study
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Boston, Massachusetts 02115


This study will determine whether or not saphenous vein [arterial] bypass grafts in the leg relax in response to increases in blood flow.

Study summary:

Subjects who have undergone saphenous vein [arterial] bypass grafts from the femoral to above-knee popliteal artery will undergo ultrasound imaging at rest, and again after 5 minutes of blood pressure cuff occlusion of the calf. (at 1 minute and 15 minutes) Subjects will then be given sub-lingual nitroglycerin, and repeat ultrasound will be performed 3 minutes later. Following 10 minutes of rest, subjects will be given intravenous L-NMMA, a specific nitric oxide inhibitor, to help determine the responsible agent of the vein graft flow mediated dilation.


Inclusion Criteria: - Adults who have undergone femoral artery to above-knee popliteal artery saphenous vein bypass grafts Exclusion Criteria: - Amputation beyond the toes - Critical limb ischemia defined as rest pain, non-healing ulceration or gangrene - Pregnancy



Primary Contact:

Principal Investigator
Joshua A. Beckman, M.D.
Brigham and Women's Hospital

Backup Contact:


Location Contact:

Boston, Massachusetts 02115
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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