St. Louis, Missouri 63110


To determine the pharmacokinetics of methadone in children and adults with SCD who are experiencing a painful episode.


Inclusion Criteria: - Greater than or equal to 7 years and less than or equal to 40 years - Confirmed diagnosis of any form of sickle cell disease, including sickle cell anemia, sickle-hemoglobin C disease, and sickle-B thalassemia - Currently experiencing a vaso-occlusive episode (VOE), defined as acute pain in the extremities - Admitted to the inpatient unit for further treatment - Started on morphine patient controlled analgesia and infusion for pain management Exclusion Criteria: - Diagnosis of acute chest syndrome - New focal neurologic findings or clinical concern of stroke - Aplastic crisis with hemoglobin 2 g/dl below steady-state value - Allergy to morphine or methadone - Any other medical condition that the attending physician deems to be a contraindication to therapy - Liver or renal insufficiency or failure, and congestive heart failure



Primary Contact:

Principal Investigator
Evan D Kharasch, MD, PhD
Washington University School of Medicine

Backup Contact:


Location Contact:

St. Louis, Missouri 63110
United States

Evan D Kharasch, MD, PhD
Phone: 314-362-7551

Site Status: Recruiting

Data Source:

Date Processed: October 09, 2019

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