Expired Study
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Boston, Massachusetts 02111


Purpose:

Although acetaminophen is the most commonly used nonprescription drug in the USA, little is known regarding the influence of genes and race/ethnicity on acetaminophen disposition. The investigators long-term goal is to understand the causes of differences in acetaminophen disposition between people that are the result of genetic variation and ethnicity and may predispose individuals to a higher risk of acetaminophen hepatotoxicity. The aim of this particular study is to measure the rate of elimination of acetaminophen via the 3 main pathways (glucuronidation, sulfation and oxidation) in self-identified White-Americans (n=100) and African-Americans (n=100). These rates will then be correlated with selected genetic polymorphisms in genes encoding enzymes involved in acetaminophen metabolism. Two main hypotheses will be tested: 1. African-Americans eliminate acetaminophen more rapidly by glucuronidation than do White-Americans. 2. Elimination via glucuronidation, sulfation, and oxidation in subjects will be significantly correlated with the presence of polymorphisms in the UGT1A6, SULT1A1, and CYP2E1 genes, respectively.


Criteria:

Inclusion Criteria: - self-declared white/Caucasian - self-declared African-American - active - ambulatory - no evidence of medical disease Exclusion Criteria: - alcohol use of 3 or more drinks per day - HIV or hepatitis (B or C) infection - isoniazid - disulfiram - phenobarbital - phenytoin - carbamazepine - rifampicin - valproic acid - probenecid - St. John's Wort


NCT ID:

NCT00768716


Primary Contact:

Principal Investigator
Michael H Court, BVSc, PhD
Tufts University


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02111
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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